Sizopin 100mg Tablet 10pcs

Uses of Sizopin 100

• Schizophrenia

How does Sizopin 100 work?

Sizopin 100 works by binding to certain receptors and inhibiting the release of the chemical substances that cause psychotic symptoms.

Side Effects of Sizopin 100

Common side effects include constipation, dizziness, drowsiness, headaches, and excessive salivation. Less frequent effects include dry mouth, abdominal discomfort, and unexpected weight gain.

Quick Suggestions:

• Sizopin 100mg Tablet helps treat schizophrenia in people for whom other medicines are ineffective or not tolerated.
• Take it with or without food, preferably at the same time every day.
• It can cause dizziness and sleepiness. Be cautious while driving or doing anything that requires concentration.
• It may cause low blood pressure and dehydration. Drink plenty of fluids and rise slowly from a sitting or lying position.
• It may increase your weight, blood sugar, and cholesterol. Eat healthy, exercise regularly, and monitor your blood levels regularly.
• Your doctor may get regular blood tests done to monitor your blood cells during treatment with this medicine. Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, or rash.
• Do not stop taking Sizopin 100mg Tablet without talking to your doctor first as it may cause worsening of symptoms.

Indication of Sizopin 100

Sizopin (Clozapine) is primarily used to treat schizophrenia in patients resistant to or intolerant of traditional antipsychotic medications. It is also indicated for managing psychosis related to Parkinson's disease.

Pharmacology

Clozapine is an atypical antipsychotic that binds to dopamine receptors differently than typical antipsychotics, particularly with a high affinity for the D4 receptor. This selective binding reduces extrapyramidal side effects, as Clozapine is more active in limbic dopamine receptors than striatal ones. It also antagonizes adrenergic, cholinergic, histaminergic, and dopaminergic receptors.

Dosage & Administration of Sizopin 100

• Schizophrenia: Start with 12.5 mg once or twice daily, gradually increasing to a target dose of 200-450 mg/day (maximum 900 mg/day).
• Parkinson's disease-related psychosis: Start with 12.5 mg at bedtime, gradually increasing to a usual range of 25-37.5 mg, with a maximum dose of 100 mg/day.

Interaction

Clozapine may interact with other CNS-active drugs and alcohol, potentially causing orthostatic hypotension. Its high protein-binding affinity may lead to displacement interactions with medications like warfarin and digoxin. Carbamazepine and Clozapine should not be used together, as Carbamazepine can lower Clozapine levels.

Contraindications

Clozapine is contraindicated in patients with severe cardiac disorders, renal impairment (creatinine clearance <10 mL/min), a history of neutropenia or agranulocytosis, bone marrow disorders, paralytic ileus, and severe CNS depression.

Pregnancy & Lactation

Clozapine has not been well-studied in pregnant women. It should be used in pregnancy only if necessary. Clozapine is excreted in animal milk, and breastfeeding should be avoided while on this medication.

Precautions & Warnings

Clozapine must be discontinued gradually to avoid withdrawal symptoms like psychosis and cholinergic rebound. Agranulocytosis is a serious side effect, so weekly WBC monitoring is required during the first six months, followed by biweekly checks. Clozapine can cause cognitive impairment, seizures, hyperglycemia, and other complications, particularly in the elderly and those with pre-existing conditions.

Storage:

Store below 30°C, away from light and out of reach of children.